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Approved Use: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).
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About classic CAH

CAH, or congenital adrenal hyperplasia, is a rare, lifelong genetic condition involving the adrenal glands.

You may already know that CAH leads to hormone imbalances due to a lack of an enzyme called 21-hydroxylase (21-OH). Too little cortisol due to CAH can result in nausea, dizziness, and even adrenal crisis. But did you know that the inability to make cortisol and resulting low cortisol levels can also cause too many androgens?

When the adrenal glands can't make cortisol, they end up using ingredients such as 17-OHP to make the hormones they can make—androgens.

Adrenal gland illustration

In people with CAH:

  • The body makes too little cortisol…
  • …and too much ACTH and androgens.
  • The salt-wasting type of CAH can mean too little aldosterone, too.
Know Your Labs
Download a printable guide that reviews the types of labs and screenings your doctor may order for CAH and why each is important.
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Lauren has classic CAH, is taking CRENESSITY, and was compensated by Neurocrine to share her story. Dr. Lin is an employee of Neurocrine.

Treating CAH with steroids alone is often a compromise between competing health risks

Steroids, in lower doses, can be used effectively to replace cortisol but often are not enough to treat excess ACTH and androgens.
Higher steroid doses can be used to manage excess ACTH and androgens; however, those high doses carry additional health risks.

Symptoms of excess ACTH and androgens may include:

  • Early puberty
  • Short stature
  • Irregular periods
  • Infertility
  • Acne
  • Excessive hair growth
  • Mental health issues
  • Testicular and ovarian adrenal rest tumors (TARTs and OARTs)

Risks of high-dose steroids may include:

  • Obesity
  • Diabetes
  • Low bone density (osteoporosis)
  • Anxiety
  • Depression
  • Memory issues
  • High blood pressure
  • High cholesterol
  • Heart disease
2 out of 3

Based on two studies, 2 out of 3 people with CAH have poorly managed androgen levels

1 out of 3

A separate study found that 1 out of 3 young adults with CAH is already being treated for conditions associated with taking high-dose steroids

CRENESSITY can address 2 treatment goals for people with classic CAH: maintaining or lowering androgen levels and enabling lower steroid doses.
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Doctor discussing CRENESSITY with a patient

Is CRENESSITY
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Reach out to your child's doctor to find out if CRENESSITY might be right for you. Create a customized guide to help start the conversation—whether at an appointment or via phone, email, or patient portal.

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Please see full Important Safety Information

Approved Uses:

CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.

CRENESSITY may cause serious side effects, including:

Allergic reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY.

Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain.

The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds.

These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.

Please see full Important Safety Information

Approved Uses: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.