Homepage | CRENESSITY® (crinecerfont)

Approved Use: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

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IT'S OUR TIME

With CRENESSITY, you can manage classic CAH like never before

Select an image to explore real experiences with CRENESSITY

*Actor portrayals.

With CRENESSITY, you can manage classic CAH like never before

Select an image to explore real experiences with CRENESSITY

About CRENESSITY

About CRENESSITY

Hear Paul talk about what it was like to start CRENESSITY

CRENESSITY offers a groundbreaking approach to managing classic CAH. CRENESSITY is not a steroid and offers a more targeted way to lower androgens. Because of this, it enables lower steroid doses, too.

How well CRENESSITY works and its safety were studied in the largest clinical trial program ever for a classic CAH treatment.

The studies showed that CRENESSITY can help you or your child meet your treatment goals: reducing androgens, reducing steroids, or both.

View the clinical study results to learn more about the safety of CRENESSITY and how well it works:

Watch a brief intro to CRENESSITY and how it may help people with classic CAH.

Lauren has classic CAH, is taking CRENESSITY, and was compensated by Neurocrine to share her story. Dr. Lin is an employee of Neurocrine.

Doctor Discussion Guide

Start the conversation about CRENESSITY.

Reach out to your doctor to find out if CRENESSITY might be right for you. Create a customized guide to help start the conversation—whether at an appointment or via phone, email, or patient portal.

We have resources tailored just for you

Learn more about taking CRENESSITY and discover how Neurocrine Access Support can provide one-on-one help navigating insurance, identifying financial support options, and refill assistance.

Taking CRENESSITY Neurocrine Access Support

Explore how CAH affects the body and how CRENESSITY works

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Next: About CAH

Please see full Important Safety Information

Approved Uses:

CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.

CRENESSITY may cause serious side effects, including:

Allergic reactions. Symptoms of an allergic reaction include tightness of the throat, trouble breathing or swallowing, swelling of the lips, tongue, or face, and rash. If you have an allergic reaction to CRENESSITY, get emergency medical help right away and stop taking CRENESSITY.

Risk of Sudden Adrenal Insufficiency or Adrenal Crisis with Too Little Glucocorticoid (Steroid) Medicine. Sudden adrenal insufficiency or adrenal crisis can happen in people with congenital adrenal hyperplasia who are not taking enough glucocorticoid (steroid) medicine. You should continue taking your glucocorticoid (steroid) medicine during treatment with CRENESSITY. Certain conditions such as infection, severe injury, or shock may increase your risk for sudden adrenal insufficiency or adrenal crisis. Tell your healthcare provider if you get a severe injury, infection, illness, or have planned surgery during treatment. Your healthcare provider may need to change your dose of glucocorticoid (steroid) medicine.

Before taking CRENESSITY, tell your healthcare provider about all of your medical conditions including if you: are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

The most common side effects of CRENESSITY in adults include tiredness, headache, dizziness, joint pain, back pain, decreased appetite, and muscle pain.

The most common side effects of CRENESSITY in children include headache, stomach pain, tiredness, nasal congestion, and nosebleeds.

These are not all the possible side effects of CRENESSITY. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths: CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.

Please see full Important Safety Information

Approved Uses: CRENESSITY (crinecerfont) is a prescription medicine used together with glucocorticoids (steroids) to control androgen (testosterone-like hormone) levels in adults and children 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

Do not take CRENESSITY if you: Are allergic to crinecerfont, or any of the ingredients in CRENESSITY.